
Mexiletine hydrochloride
CAS No. 5370-01-4
Mexiletine hydrochloride( Ko 1173 )
Catalog No. M14905 CAS No. 5370-01-4
Antiarrhythmic agent pharmacologically similar to LIDOCAINE. It may have some anticonvulsant properties.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
50MG | 32 | In Stock |
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100MG | 43 | In Stock |
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200MG | 53 | In Stock |
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500MG | 61 | In Stock |
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1G | Get Quote | In Stock |
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Biological Information
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Product NameMexiletine hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionAntiarrhythmic agent pharmacologically similar to LIDOCAINE. It may have some anticonvulsant properties.
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DescriptionAntiarrhythmic agent pharmacologically similar to LIDOCAINE. It may have some anticonvulsant properties.
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In Vitro——
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In VivoAnimal Model:Male Sprague-Dawley rats with Oxaliplatin (HY-17371)-induced neuropathic pain Dosage:Oxaliplatin (4 mg /kg) and Mexiletine(10, 30, 100 mg/kg) Administration:Oxaliplatin, Intraperitoneal injection (i.p.)in days 1, 2, 8, 9, 15, 16, 22, and 23; Mexiletine, Oral gavage (p.o.), acute administration Result:100 mg/kg completely reversed the reduction of 50% paw withdrawal threshold by Oxaliplatin at 60 min after administration in the von Frey test, completely reversed the increase of number of withdrawal responses at 60 and 120 min after administration in the acetone test. 30 mg/kg partly reversed the symptom and 10 mg/kg did not reverse any symptom. The effect disappeared by 180 min after administration.
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SynonymsKo 1173
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PathwayEndocrinology/Hormones
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TargetAhR
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RecptorAhR| Voltage-gated sodium channel
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Research AreaCardiovascular Disease
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Indication——
Chemical Information
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CAS Number5370-01-4
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Formula Weight215.72
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Molecular FormulaC11H18ClNO
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Purity>98% (HPLC)
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SolubilityEthanol: 43 mg/mL (199.33 mM); Water: 43 mg/mL (199.33 mM); DMSO: 43 mg/mL (199.33 mM)
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SMILES[Cl-].CC([NH3+])COC1=C(C)C=CC=C1C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Valdivia CR, et al. Cardiovasc Res. 2002 Aug 1;55(2):279-89.
molnova catalog



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