Mexiletine hydrochloride

CAS No. 5370-01-4

Mexiletine hydrochloride( Ko 1173 )

Catalog No. M14905 CAS No. 5370-01-4

Antiarrhythmic agent pharmacologically similar to LIDOCAINE. It may have some anticonvulsant properties.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
50MG 32 In Stock
100MG 43 In Stock
200MG 53 In Stock
500MG 61 In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Mexiletine hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    Antiarrhythmic agent pharmacologically similar to LIDOCAINE. It may have some anticonvulsant properties.
  • Description
    Antiarrhythmic agent pharmacologically similar to LIDOCAINE. It may have some anticonvulsant properties.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Male Sprague-Dawley rats with Oxaliplatin (HY-17371)-induced neuropathic pain Dosage:Oxaliplatin (4 mg /kg) and Mexiletine(10, 30, 100 mg/kg) Administration:Oxaliplatin, Intraperitoneal injection (i.p.)in days 1, 2, 8, 9, 15, 16, 22, and 23; Mexiletine, Oral gavage (p.o.), acute administration Result:100 mg/kg completely reversed the reduction of 50% paw withdrawal threshold by Oxaliplatin at 60 min after administration in the von Frey test, completely reversed the increase of number of withdrawal responses at 60 and 120 min after administration in the acetone test. 30 mg/kg partly reversed the symptom and 10 mg/kg did not reverse any symptom. The effect disappeared by 180 min after administration.
  • Synonyms
    Ko 1173
  • Pathway
    Endocrinology/Hormones
  • Target
    AhR
  • Recptor
    AhR| Voltage-gated sodium channel
  • Research Area
    Cardiovascular Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    5370-01-4
  • Formula Weight
    215.72
  • Molecular Formula
    C11H18ClNO
  • Purity
    >98% (HPLC)
  • Solubility
    Ethanol: 43 mg/mL (199.33 mM); Water: 43 mg/mL (199.33 mM); DMSO: 43 mg/mL (199.33 mM)
  • SMILES
    [Cl-].CC([NH3+])COC1=C(C)C=CC=C1C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Valdivia CR, et al. Cardiovasc Res. 2002 Aug 1;55(2):279-89.
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